English Intern
    Lehrstuhl für Toxikologie

    Preliminary Program

    9:00 – 10:00

    Get Together

    10:00 – 10:20

    Prof. Dr. M.W. Anders, Chair, University of Rochester, NY, USA
    Welcome address

    10:20 – 11:00

    Prof. Dr. Dan Liebler, Vanderbilt University, Nashville, TN, USA
    Global Analysis of Lipid Electrophile Protein Adducts and Redox Modifications

    11:00 – 11:40

    Coffee break

    11:40 – 12:20

    PD Dr. Angela Mally, University of Würzburg, Germany
    Molecular and Cellular Consequences of Covalent Target Protein Modification

    12:20 – 13:00

    Prof. Dr. Bob van de Water, Leiden University, The Netherlands
    Mapping Cellular Signaling Networks Controlling Stress Response Pathways in Adverse Drug Reactions

    13:00 – 14:00


    14:00 – 14:40

    Prof. Dr. Wolfgang Dekant, University of Würzburg
    Biotransformation, Reactive Intermediates, and Covalent Binding: Two Faces of Glutathione S-Conjugate Formation

    14:40 – 15:20

    Dr. Alexander Amberg, Drug Safety Evaluation, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main
    In silico/Computational Prediction of Reactive Intermediates: Structural Alerts (Toxicophore), Structure-Toxicity Relationships, Pathways of Reactive Intermediates Formation

    15:20 – 16:00

    Coffee break

    16:00 – 16:40

    PD Dr. Stefan O. Müller, Non-Clinical Safety Lead, Merck KGaA, Darmstadt, Germany
    Hepatocyte Models for Reactive Metabolites and Toxicity Prediction


    16:40 – 17:30

    Overall discussion and conclusions






    Lehrstuhl für Toxikologie
    Versbacher Straße 9
    97078 Würzburg


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