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Deutsch Intern
    Department of Toxicology

    Main objectives

    The overall objective of Risk-IT is to accelerate the transition of chemical safety testing from animal-based approaches with limited predictivity for human risk to more predictive, animal-sparing solutions by developing new mechanism-based in vitro methods and providing a proof-of-concept for the successful integration of mechanistic endpoints and QIVIVE modelling for regulatory purposes.

    The main scientific aims of Risk-IT are:

    • to integrate expert knowledge and existing and newly developed ‘omics data to develop a systems-toxicology-based mechanistic framework for drug/chemical-induced nephrotoxicity in line with the AOP concept
    • to use the developed mechanistic framework to establish a fit-for-purpose, battery of mechanism-based in vitro assays for prediction of human  drug/chemical safety for nephrotoxicity
    • to provide a proof-of-concept for the successful integration of new mechanism-based in vitro methods and QIVIVE into a tiered testing strategy that is fit-for-purposes of regulatory decision making
    • to assess the confidence of risk assessment based on in vitro data

    Workpackage design

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    Data privacy protection

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    Contact

    Universität Würzburg
    Sanderring 2
    97070 Würzburg

    Phone: +49 931 31-0
    Fax: +49 931 31-82600

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    Sanderring
    Sanderring
    Röntgenring
    Röntgenring
    Hubland Nord
    Hubland Nord
    Hubland Süd
    Hubland Süd
    Campus Medizin
    Campus Medizin