Deutsch Intern
    Department of Toxicology

    Research Activities

    The Institute in Würzburg has a tract record of internationally acclaimed research on the biotransformation of nephrotoxicants and studies related to interactions of biological reactive intermediates with cellular macromolecules and function. Part of this is based on the application of in vitro models (freshly isolated renal cell preparations, renal cell culture, subcellular fractions and isolated perfused organs) to study mechanisms of toxicity.

    The laboratory is funded by the Deutsche Forschungsgemeinschaft, the Bundesministerium für Forschung und Technologie, Umweltbundesamt, US EPA, US HEI, industry and a number of foundations. The equipment is at the cutting edge of technology and includes gas chromatography-mass spectrometry with different ionisation techniques, electrospray mass spectrometry (MS/MS), high performance liquid chromatography with fluorescence, diode array and UV-detectors, and a full array of in vitro techniques. Chemical and radiochemical synthesis and a 600 MHz (1H)nuclear magnetic resonance spectrometer is available on the campus.

    The laboratory is focusing on the application of mechanistic toxicology to risk assessment of synthetic chemicals. Most aspects of the work performed use analytical procedures (gas chromatography / mass spectrometry and HPLC) to quantify xenobiotic metabolites in biological systems ranging from enzymatic incubations to occupationally exposed humans. Moreover, the laboratory uses biochemically methods to characterise enzymes involved in the biotransformation of xenobiotics.


    Funded Projects

    Contact

    Universität Würzburg
    Sanderring 2
    97070 Würzburg

    Phone: +49 931 31-0
    Fax: +49 931 31-82600

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    Sanderring Röntgenring Hubland Nord Hubland Süd Campus Medizin