Deutsch Intern
    Department of Toxicology

    Molecular mechanisms and carcinogenicity of the mycotoxin Ochratoxin A

    Summary

    The mycotoxin and food contaminant ochratoxin A (OTA) is one of the most potent renal carcinogens studied to date. The molecular events leading to renal tumor formation by OTA are still poorly understood, but increasing evidence suggests that OTA is not a mutagenic, DNA-reactive carcinogen. Recent work in our laboratory provide important new evidence in support of a mechanism of OTA carciogenicity involving disruption of mitosis, presumably through interference with key regulators of chromosome separation and progression through mitosis, resulting in blocked or asymmetric cell division, accompanied by an increased risk of aneuploidy acquisition and subsequent tumor formation.

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