Participant 2: ISS
Istituto Superiore di Sanità – Environment and Primary Prevention Department – Molecular Epidemiology Unit- Rome Italy (www.iss.it)
Participant leader: Dr. Eugenia Dogliotti
Relevant experience and laboratory resources
The “Istituto Superiore di Sanità” (ISS) is the main Italian institute of scientific-technical research, control and advice in public health. ISS is organized in eight Departments. The Department of Environment and Primary Prevention is a multidisciplinary body that combines chemical, toxicological, biological, microbiological and epidemiological expertise in the qualitative and quantitative assessment of risks for human health and for the environment. Three Units of the Depatment of Environment and Primary Prevention will contribute to the project, viz. Genetic Toxicology (director R.Crebelli), Experimental and Computational Carcinogenesis (director M.Bignami) and Molecular Epidemiology (director E.Dogliotti). The leading scientists of these units have been involved in active research in the field of environmental and molecular mutagenesis and carcinogenesis since the seventhies, also in the framework of EC funded projects. All the experimental units have available excellent laboratory facilities, which were recently renewed, and modern equipments for all kinds of biological research, including dedicated image analysis systems, Real Time-PCR, automatic sequence analyzer, etc. Moreover, a modern, dedicated structure for animal housing and experimentation is available in ISS. The main ongoing research activities in the experimental units involved in this project concern the identification and characterization of genotoxic risks of environmental factors, and molecular mechanisms of mutagenesis and carcinogenesis; moreover, it is providing scientific consultancy on issues related to mutagenesis and carcinogenesis at national and international level (e.g. EU/EC, IARC, NATO, OECD, WHO).
Principal staff involved:
Dr. Eugenia Dogliotti is presently Director of the Unit of Molecular Epidemiology of the ISS. She is member of the National Committee on Novel Food and Codex Alimentarius as expert in the area: “Genotoxicity and recombinant DNA”. She has a long-standing experience in the analysis of the molecular mechanisms of mutagenesis and DNA repair of environmental agents in mammalian cell systems. She is the author of over 80 publications in the area of mutagenesis and DNA repair in peer-reviewed journals.
Dr. Riccardo Crebelli is presently member of the Scientific Panel on Food Additives, Flavouring and Food Contact Materials of EFSA, and member of national advising committees on toxicology. He has previously served as expert for the former EU Scientific Committee on Food. He is director of the unit of Genetic Toxicology at ISS. He is author of more than 80 research publications in the field of mutagenesis in peer reviewed journals, beyond books chapters, congress proceedings, and technical reports.
Dr. Margherita Bignami is presently Director of the Unit of Experimental Carcinogenesis of the ISS. She is a member of the committee for preclinical safety evaluation (mutagenesis and carcinogenesis) of new medicinal products. She is currently involved in studies on the mechanisms of neoplastic transformation by chemical carcinogens and on the role of DNA repair in controlling genomic instability. She is the author of close to 100 research publications in the field of mutagenesis and carcinogenesis in peer-reviewed journals.
Prof. Angelo Carere is presently member of the Scientific Panel on Contaminants of EFSA. He was member of the EC Scientific Committee on Food, Director of the Laboratory of Comparative Toxicology at ISS, President of the European Environmental Mutagen Society, and covered a number of other positions at the national and international level. He is author of more than 100 scientific papers in the field of environmental mutagenesis, toxicology and risk assessment.
Other investigators: the main scientists mentioned above will coordinate the work of an experienced team of postdoc researchers (4 units), young researchers (5 units) and technicians (6 units).