Strep Furan-Ra (FP 6)


    Participant 4: UNI BHAM


    School of Biosciences, University of Birmingham, U. K. (www.bham.ac.uk)
    Participant leader: Prof. Dr. Kevin Chipman


    Professor Chipman completed his BSc in Biological Sciences (Leicester) and PhD (Reading). After postdoctoral work at St Mary’s Hospital Medical School and research as Senior Scientific Officer at Beecham Pharmaceuticals, he was appointed as Lecturer at the University of Birmingham (1983) where he now holds a Chair in Cell Toxicology. He has ca. 150 peer reviewed publications on the mechanisms of chemical toxicity and application to the development of biomarkers for pollutant impacts. Recently, attention has moved to toxicogenomics both in studies of transcriptomics in mammalian cells exposed to model toxicants and whole organism responses. Furan has been the topic of recent research in collaboration with Industry. In this work the pathological changes and associated gene expression modifications have been investigated in the context of cholangiocarcinoma in the rat. These studies are currently being prepared for publication. Kevin’s research group totals 15 postgraduate and postdoctoral researchers (including collaborations) reflecting current or recent grant support from NERC, Industry, EU, CEFAS, CEFIC-LRI, LRF, BBSRC, Dept Health, and CRUK. NERC funded preliminary work leading to current transcriptomics in the flounder and in the stickleback funded by the GENIPOL EU and NERC PG&P programmes. Kevin sits on various advisory boards including (recently) the FSA Committee on Toxicity, MCA Committee Safety of Medicines and is a member of the NERC College. He was recently Chairman of the Scientific Committee of the British Toxicology Society and is Director of the International Union of Toxicology. He directs the MSc Toxicology course and a new MRes in Molecular Mechanistic Toxicology supported by BBSRC and EU. In the past year he has been an invited speaker at 6 International Meetings on subjects relating to toxicogenomics and cancer biomarkers.


    Principal staff involved:
    In the School of Biosciences, Prof. Chipman is the leader of the Molecular Pathobiology Research Theme with links to Environmental Biology and to Molecular Biology. Labs are newly refurbished and well equipped. The transcriptomics capability in the “Genomics and Proteomics” facility at Birmingham is well established (originally funded by JIF (£3.4M) and already supported grant-funded projects over the past few years, with over £2M from NERC. The School of Biosciences hosts several Computational Biology groups including traditionally strong Structural Biology and protein modelling. More recently the School has initiated a Bioinformatics program involving the appointment of several new PIs and the establishment of collaborative links with the Schools of Engineering, Mathematics and Statistics.